分子発生生物学研究室

原著論文
  • Toné, S., Tanaka, S., Kato, Y. The inhibitory effect of 5-bromodeoxyuridine on the programmed cell death in the chick limb. Develop. Growth & Differ. 25: 381-391 (1983)
  • Toné, S. , Kato, Y. Method of vital staining of mouse eggs using Hoechst dye. Jpn. J. Animal Reprod. 32: 101-105 (1986)
  • Sasaki, H., Toné, S., Nakazato, M., Yoshioka, K., Matsuo, H., Kato, Y., Sakaki, Y Generation of transgenic mice producing a human transthyretin variant: a possible mouse model for familial amyloidotic polyneuropathy. Biochem. Biophys. Res. Commun., 139: 794-799 (1986)
  • Fujimoto, H., Erickson, R. P., Toné, S. Changes in polyadenylation of lactate dehydrogenase-X mRNA during spermatogenesis in mice. Molecular Reproduction & Development, 1: 27-34 (1988)
  • Toné, S., Tanaka, S., Kato, Y The cell cycle and cell population kinetics in the programmed cell death in the limb buds of normal and 5-bromodeoxyuridine-treated chick embryos. Develop. Growth & Differ., 30: 261-270. (1988)
  • Toné, S., Takikawa, O., Habara-Ohkubo, A., Kadoya, A., Yoshida, R. and Kido, R Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA. Nucleic Acids Research, 18: 367-367. (1990)
  • Toné, S., Katoh, Y., Fujimoto. H., Togashi, S., Yanazawa, M., Kato, Y., Higashinakagawa, T. Expression of inhibin -subunit gene during mouse gametogenesis. Differentiation, 44: 62-68. (1990)
  • Kadoya, A., Toné, S., Maeda, H., Minatogawa, Y., Kido, R Gene structure of human indoleamine 2,3-dioxygenase gene. Biochem. Biophys. Res. Commun., 189: 530-536. (1992)
  • Minatogawa, Y., Toné, S., Allsop, J., Purdue, P. E., Takada, Y., Danpure, C. J. Kido, R. A serine-to-phenylalanine substitution leads to loss of alanine: glyoxylate aminotransferase catalytic activity and immunoreactivity in a patient with primary hyperoxaluria type 1. Human Molecular Genetics, 1: 643-644 (1992)
  • Toné, S., Tanaka, S, Minatogawa, Y.,Kido, R DNA fragmentation during programmed cell death in the chick limb buds Experimental Cell Research, 215: 234-236. (1994)
  • Toné, S., Kadoya, A., Maeda, H., Minatogawa, Y., Kido, R. Assignment of human indoleamine 2,3-dioxygenase gene to chromosome 8 using polymerase chain reaction. Human Genetics, 93: 201-203 (1994)
  • Araki, M., Toné, S., Akagawa, K. Kimura H. High potassium promotes differentiation of retinal neurons but does not favor rod differentiation. Developmental Brain Research, 89: 103-114 (1995)
  • Toné,S., Kurihara, K., Ohyama,T., Shinohara, K,. Cloning of DNA fragments derived from 30 kbp DNA occuring in early phase of apoptosis Nucleic Acids, 35: 216-217 (1996)
  • Shinohara, K., Tomioka, M., Nakano, H., Toné,S., Ito, H., Kawashima, S. Apoptosis induction resulting from proteasome inhibition. Biochem. Journal, 317: 385-388 (1996)
  • Suzuki, H., Uemura, S., Toné, S., Iizuka, T., Koike, M., Hirayama, K., Maeda, J. Effects of immunoglobulin and gamma-interferon on the production of tumor necrosis factor-a and interleukin-1by the peripheral blood monocytes in the acute phase of Kawasaki disease.  European J. of Pediatrics, 155: 291-296 (1996)
  • Southan, MD, Truscott, RJW, Jamie JF, Pelosi L, Walker MJ, Maeda H, Iwamoto Y, Toné S. Structural requirements of the competitive binding site of recombinant human indoleamine 2,3-dioxygenase. Medicinal Chemistry Research, 343-352 (1996)
  • Toné, S., Tanaka S. Analysis of relationship between programmed cell death and cell cycle in limb-bud. Hormone Res., 48: 5-10 (1997)
  • Nakano H, Kurihara K, Okamoto M, Toné S, Shinohara K. Heat-induced apoptosis and p53 in cultured mammalian cells. Int J Radiat Biol. 71: 519-529 (1997)
  • Toma S, Nakamura M, Toné S, Okuno E, Kido R, Breton J, Avanzi N, Cozzi L, Speciale C, et al. Cloning and recombinant expression of rat and human kynureninase. FEBS Lett. 408:5-10 (1997)
  • Ueyama T, Kawai Y, Nemoto K, Sekimoto M, Toné S, Senba E. Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain. Neurosci. Res. 28: 103-110 (1997)
  • Morioka K, Toné S, Mukaida M, Takano-Ohmuro H. The apoptotic and nonapoptotic nature of the terminal differentiation of erythroid cells. Exp. Cell Res. 240: 206-217 (1998)
  • Kitauchi S, Yamanouchi H, Hirano N, Toné S, Shiino M Effect of neonatal thyroidectomy on growth hormone secretion in the rat. J. Endocrinol. 157: 245-250 (1998)
  • Tanaka S, Suzuki K, Watanabe M, Matsuda A, Toné S, Koike T. Upregulation of a new microglial gene, mrf-1, in response to programmed neuronal cell death and degeneration. J. Neurosci. 18: 6358-6369 (1998)
  • Samejima K, Toné S, Kottke TJ, Enari M, Sakahira H, Cooke CA, Durrieu F, Martins LM,Nagata S, Kaufmann SH, Earnshaw WC. (1st and 2nd authors contributed equally to this work) Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution. J. Cell Biol. 143: 225-239 (1998)
  • Tsunekawa N, Matsumoto M, Toné S, Nishida T, Fujimoto H. The Hsp70 homolog gene, Hsc70t, is expressed under translational control during mouse spermiogenesis. Mol Reprod Dev. 52: 383-391 (1999)
  • Kaufmann SH, Mesner PW Jr, Samejima K, Toné S, Earnshaw WC. Detection of DNA cleavage in apoptotic cells. Methods Enzymol. 322: 3-15 (2000)
  • Kusakabe T, Sugimoto Y, Hirota Y, Toné S, Kawaguchi Y, Koga K, Ohyama T. Isolation of replicational cue elements from a library of bent DNAs of Aspergillus oryzae. Mol Biol Rep. 27: 13-19 (2000)
  • Toné S, Kubo T, Ohyama T, Kusakabe T, Minatogawa Y. Quantitation of mRNA using in vitro RNA amplification and northern hybridization. Anal Biochem. 284: 420-422 (2000)
  • Kusakabe T, Sugimoto Y, Maeda T, Nakajima Y, Miyano M, Nishikawa J, Toné S, Kawaguchi Y, Koga K, Ohyama T. Linearization and integration of DNA into cells preferentially occurs at intrinsically curved regions from human LINE-1 repetitive element. Gene 274: 271-281 (2001)
  • Fujigaki S, Saito K, Sekikawa K, Toné S, Takikawa O, Fujii H, Wada H, Noma A, Seishima M Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism. Eur J Immunol 31: 2313-2318 (2001)
  • Ikeda M, Hirokawa M, Satani N, Kinoshita T, Watanabe Y, Inoue H, Toné S, Ishikawa T, Minatogawa Y Molecular cloning and characterization of a steroid receptor-binding regulator of G-protein signaling protein cDNA Gene 273: 207-214 (2001)
  • Machida K, Tsukiyama-Kohara K, Seike E, Toné S, Shibasaki F, Shimizu M, Takahashi H, Hayashi Y, Funata N, Taya C, Yonekawa H, Kohara M.  Inhibition of cytochrome c release in Fas-mediated signaling pathway in transgenic mice induced to express hepatitis C viral proteins. J Biol Chem. 276: 12140-12146 (2001)
  • Suzuki S, Toné S, Takikawa O, Kubo T, Kohno I, Minatogawa Y. Expression of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase in early concepti. Biochem J. 355: 425-429 (2001)
  • Samejima K, Toné S, Earnshaw WC. CAD/DFF40 nuclease is dispensable for high molecular weight DNA cleavage and stage I chromatin condensation in apoptosis..  J. Biol. Chem. 276: 45427-45432 (2001)
  • Origasa M, Tanaka S, Suzuki K, Toné S, Lim B, Koike T. Activation of a novel microglial gene encoding a lysosomal membrane protein in response to neuronal apoptosis. Brain Res Mol Brain Res. 88(1-2):1-13 (2001)
  • Sato, M, Toné S, Ishikawa T, Danpure, C, Minatogawa, Y Functional analysis of the 5'-flanking region of the human alanine:glyoxylate aminotransferase gene AGXT. Biochem. Biophys. Acta 1574: 205-209 (2002)
  • Toné S, Hatada S, Kubo T, Kawashima, Minatogawa Y, Ohyama T Contamination of Escherichia coli insertion element DNA sequences in human genome databases J. Advanced Science 13: 537-540 (2002)
  • Tomioka M, Sameshima M, Nakano H, Kubo T, Shinohara K, Seyama Y, Kawashima S , Toné S   A possible intermediate step during apoptotic execution Human Cell 15: 43-51 (2002)
  • Ikeda M, Okai M, Miyoshi T, Toné S, Minatogawa Y. Transcriptional suppression of the estrogen receptor by truncated estrogen receptor-alpha. Horm Metab Res. 34(8): 425-430 (2002)
  • Akimitsu N, Kamura K, Toné S, Sakaguchi A, Kikuchi A, Hamamoto H, Sekimizu K. Induction of apoptosis by depletion of DNA topoisomerase II alpha in mammalian cells. Biochem Biophys Res Commun. 307: 301-307 (2003)
  • Kai S, Goto S, Tahara K, Sasaki A, Toné S, Kitano S: Indoleamine 2,3-dioxygenase is necessary for cytolytic activity of natural killer cells. Scand J. Immunol. 59:177-182 (2004)
  • Ishio T, Goto S, Tahara K, Toné S, Kawano K, Kitano S: Immunoactivative role of indoleamine 2,3-dioxygenase in human hepatocellular carcinoma. J Gastroenterol Hepatol. 19: 319-326 (2004)
  • Tsukiyama-Kohara K, Toné S, Maruyama I, Inoue K, Katsume A, Nuriya H, Ohmori H, Ohkawa J, Taira K, Hoshikawa Y, Shibasaki F, Reth M, Minatogawa Y, Kohara M Activation of the CKI-CDK-Rb-E2F pathway in full genome hepatitis C virus-expressing cells.  J. Biol Chem. 279: 14531-14541 (2004)
  • Kanouchi H, Nishizaki H, Minatogawa Y and Toné S Large complex formation of the inhibitor of caspase-activated DNase Apoptosis 10(3):651-656 (2005)
  • Kanouchi H, Matsumoto M, Taga M, Yamada K, Oka T, Toné S, Minatogawa Y. Nuclear transfer of perchloric acid-soluble protein by endoplasmic reticulum stressors. Protein Sci. 14(9):2344-2349 (2005)
  • Morizane Y, Mohri S, Kosaka J, Toné S, Kiyooka T, Ce Tissue Res. 324(2):301-310 (2006)
  • Kanouchi H, Miyamoto M, Oka T, Matsumoto M, Okamoto T, Toné S, Minatogawa Y. Perchloric acid-soluble protein is expressed in enterocytes and goblet cells in the intestine and upregulated by dietary lipid. Biochim Biophys Acta. 1760(9):1380-1385 (2006)
  • Okamoto T, Toné S, Kanouchi K, Miyawaki C, Ono S, Minatogawa Y Transcriptional regulation of indoleamine 2,3-dioxygenase (IDO) by tryptophan and its analogue Down-regulation of the indoleamine 2,3-dioxygenase (IDO) transcription by tryptophan and its analogue Cytotechnology 54:107–113 (2007)
  • Toné S, Sugimoto K, Tanda K, Suda T, Uehira K, Kanouchi H, Samejima K, Minatogawa Y, Earnshaw WC. Three distinct stages of apoptotic i by overexpression of rat perchloric acid-soluble protein., Mem. Fac. Agr. Kagoshima Univ, 42:5-9 (2007).
  • Nakahara M, Nagayama Y, Saitoh O, Sogawa R, Toné S, Abiru N. Expression of Immuno-Regulatory Molecules by Thyrocytes Protects NOD-H2h4 Mice from Developing Autoimmune Thyroiditis. Endocrinology. 150: 1545-1551 (2009)
  • Eguchi R, Toné S, Suzuki A, Fujimori Y, Nakano T, Kaji K, Ohta T.  Possible involvement of caspase-6 and -7 but not caspase-3 in the regulation of hypoxia-induced apoptosis in tube-forming endothelial cells.  Exp. Cell Res.  315(2):327-335 (2009)
  • Ikeda M, Inoue A, Toné, S. A focused DNA microarray analysis of estrogen-responsive genes in COS-7 cells over-expressing the estrogen receptor alpha Kawasaki Medical Journal 35(2):159-165 (2009)
  • Nagahama M, Umezaki M, Oda M, Kobayashi K, Toné S, Suda T, Ishidoh K, Sakurai J.     Clostridium perfringens iota-toxin b induces rapid cell necrosis. Infect and Immun. 79(11):4353-4560 (2011)
  • Jrad-Lamine A, Henry-Berger J, Gourbeyre P, Damon-Soubeyrand C, Lenoir A, Combaret L, Saez F, Kocer A, Toné S, Fuchs D, Zhu W, Oefner PJ, Munn DH, Mellor AL, Gharbi N, Cadet R, Aitke amember Arp6 and the histone variant H2A.Z are required for spatial positioning of chromatin in chicken cell nuclei. J Cell Sci. 125(Pt 16):3739-3743 (2012)
  • Phimsen S, Kuwahara K, Nakaya T, Ohta K, Suda T, Rezano A, Kitabatake M, Vaeteewoottacharn K, Okada S, Toné S, Sakaguchi N. Selective cell death of p53-insufficient cancer cells is induced by knockdown of the mRNA export molecule GANP. Apoptosis. 17(7):679-690 (2012)
  • Rezano A, Kuwahara K, Yamamoto-Ibusuki M, Kitabatake M, Moolthiya P, Phimsen S, Suda T, Toné S, Yamamoto Y, Iwase H, Sakaguchi N. Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survival.BMC Cancer. 13:562. (2013)
  • Nagashima F, Suzuki IK, Shitamukai A, Sakaguchi H, Iwashita M, Kobayashi T, Toné S, Toida K, Vanderhaeghen P, Kosodo Y. Novel and robust transplantation reveals the acquisition of polarized processes by cortical cells derived from mouse and human pluripotent stem cells. Stem Cells Dev. 23(18):2129-2142 (2014)
  • Yoshioka Y, Fujibayashi H, Kameda K, Kan D, Toné S, Tamura M Induction of apoptosis in Caco-2 cells by exogenously added O2_ produced by a nanodevice. Exp. Cell Res. 331, 408-415. (2015)
  • Tamura M, Kunihiro S, Hamashima Y, Yoshioka Y, Toné S, Kameda K An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells Biotechnology Reports 6, 45-50. (2015)
  • Obayashi Y, Ozaki Y, Goto S, Obayashi S, Suzumori N, Ohyama F, Toné S, Sugiura-Ogasawara1 M Role of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase in Patients with Recurrent Miscarriage American Journal of Reproductive Immunology 75, 69-77 (2016)
著書
  • Sasaki, H., Nakazato, M., Toné, S., et al. Towards establishment of an animal model for familial amyloidotic polyneuropathy: generation and characterization of transgenic mice in "Amyloid and Amyloidosis" eds. by Isobe T. et al., 399-404 p.p (Plenum Publishing Corporation) (1988)
  • 菅原勇、小路武彦、刀祢重信、他編著 細胞生物学辞典 中外医学社 1993年
  • 刀祢重信  アポトーシス 細胞機能と分子機構(木崎治俊、佐々木史江編)高等動物の発生過程におけるプログラム細胞死 102ー135pp, 中外医学社 1994年 
  • 刀祢重信 アポトーシスと医学 (山田武、橋本嘉幸編) 高等動物の発生におけるプログラム細胞死  羊土社 1995年
  • 刀祢重信、田中省二 最新アポトーシス実験法(辻本賀英、刀祢重信、山田武編) in situ end labeling ( TUNEL法)  pp. 41-48 羊土社 1995年
  • 刀祢重信  最新アポトーシス実験法(辻本賀英、刀祢重信、山田武編)アポトーシス誘導法ー肢芽in vivo と培養法  pp. 124-129 羊土社 1995年
  • Toné S.,  Programmed cell death in vertebrate development with special emphasis on apoptosis during limb morphogenesis in Apoptosis, its roles and mechanism (eds. by Yamada T and Hashimoto Y) pp.129-140 Busiess Center for Academic Societies Japan, Tokyo, 1998
  • 刀祢重信、田中省二 新アポトーシス実験法(辻本賀英、刀祢重信、山田武編)アポトーシス分子機構解析 多用される細胞・組織系 pp. 136-144 羊土社 1999年
  • 伏谷建造、刀祢重信 新アポトーシス実験法(辻本賀英、刀祢重信、山田武編)関連タンパク質の解析  2次元電気泳動法 pp. 211-223 羊土社 1999年
  • 刀祢重信 ベーシックマスター 分子生物学(東中川、大山、清水編)細胞周期と細胞分裂 pp. 270-288 オーム社 2006年
  • Sugimoto K, Toné S. Imaging of mitotic cell division and apoptotic intra-nuclear processes in multicolor in “Live Cell Imaging: Methods and Protocols” (Methods in Molecular Biology ) (2010) Humana Press
  • 刀祢重信 細胞死解析プロトコル(刀祢重信、小路武彦編)羊土社2012年
総説その他
  • 刀祢重信 胚発生におけるプログラム細胞死 実験医学 6: 445-447 (1988)
  • 刀祢重信 プログラム細胞死と細胞周期 細胞 21: 129-133 (1989)
  • 刀祢重信 私にとって分子病理学とは 病理と臨床9: 1638 (1992)
  • 刀祢重信 癌抑制遺伝子とその周辺:発生過程におけるプログラム細胞死 実験医学 10: 2284-2289 (1992)
  • 刀祢重信 発生過程でのプログラム細胞死 日経サイエンス 6月号24-29 (1993)
  • 刀祢重信, 田中省二 高等動物の発生におけるプログラム細胞死、実験医学 11: 2268-2274 (1993)
  • 刀祢重信 発生とアポトーシス、最新医学49: 1089-1095 (1994)
  • 刀祢重信 形態形成におけるプログラムされた細胞死 J. Reproduction and Development 42: 127-133 (1996)
  • 津吹聡、富岡正典、刀祢重信、川島誠一 神経細胞の分化とアポトーシスー プロテオソームの関与 細胞工学 15: 950-957 (1996)
  • 刀祢重信  TUNEL法 Surgery Frontier 3: 183-186 (1996)
  • 刀祢重信  個体発生とアポトーシス. 現代化学増刊35: 145-150 (1997)
  • 刀祢重信  発生過程におけるアポトーシス. 医学のあゆみ187: 441-446 (1998)
  • 刀祢重信  発生過程のアポトーシス. 心臓 30: 785-791 (1998)
  • 刀祢重信  アポトーシスにおける核構造の変化 実験医学20: 1711-15 (2002)
  • 刀祢重信. アポトーシスにおける核のダイナミクス 核凝縮もプログラムされているか? 蛋白質・核酸・酵素 51(14 suppl):2250-2255(2006)
  • 刀祢重信  ニュートンムック 人体を支配するしくみ 起源・遺伝子から ナノテク医療まで (2006)
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