Research Publications

Research Papers

  1. Takahashi S*, Oshige M, Katsura S, Nagahara Y. (2023)
    A new fluorescence labeling method for molecular analysis of double-stranded DNA.
    Analytical Biochemistry,  https://doi.org/10.1016/j.ab.2022.115000
  2. Semba Y, Yamamoto S, Takahashi S, Shinomiya T, Nagahara Y. (2022)
    c-kit inhibitor masitinib induces reactive oxygen species-dependent apoptosis in c-kit-negative HepG2 cells.
    European Journal of Pharmacology,  https://doi.org/10.1016/j.ejphar.2022.175183
  3. Vavricka CJ#, Takahashi S# (#Contributed equally), Watanabe N, Takenaka M, Matsuda M, Yoshida T, Suzuki R, Kiyota H, Li J, Minami H, Ishii J, Tsuge K, Araki M, Kondo A, Hasunuma T. (2022)
    Machine learning discovery of missing links that mediate alternative branches to plant alkaloids.
    Nature Communications,  https://doi.org/10.1038/s41467-022-28883-8
  4. Takahashi S, Shinomiya T, Nagahara Y. (2022)
    Azoxystrobin Induces Apoptosis and Cell Cycle Arrest in Human Leukemia Cells Independent of p53 Expression.
    Anticancer Research, https://doi.org/10.21873/anticanres.15598
  5. 高橋俊介, 侭田陽平, 岸一希, 平賀諒太, 大重真彦, 桂進司 (2022)
    低周波交流電界印加によるタンパク質固定のリアルタイム解析
    静電気学会誌, http://www.iesj.org/content/files/pdf/papers/46/46-1-14.pdf
  6. Vavricka CJ, Yoshida T, Kuriya Y, Takahashi S, Ogawa T, Ono F, Agari K, Kiyota H, Li J, Ishii J, Tsuge K, Minami H, Araki M, Hasunuma T, Kondo A. (2019)
    Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids.
    Nature Communications, https://doi.org/10.1038/s41467-019-09610-2
  7. Takahashi S, Kishi K, Hiraga R, Hayashi K, Mamada Y, Oshige M, Katsura S. (2018)
    A New Method for Immobilization of His-Tagged Proteins with the Application of Low-Frequency AC Electric Field.
    Sensors (Basel), https://doi.org/10.3390/s18030784
  8. Takahashi S, Motooka S, Kawasaki S, Kurita H, Mizuno T, Matsuura SI, Hanaoka F, Mizuno A, Oshige M, Katsura S. (2018)
    Direct single-molecule observations of DNA unwinding by SV40 large tumor antigen under a negative DNA supercoil state.
    Journal of Biomolecular Structure and Dynamics, https://doi.org/10.1080/07391102.2016.1269689
  9. 平賀諒太, 岸一希, 高橋俊介, 宮田英史, 大重真彦, 桂進司 (2017)
    高電圧パルス印加による「その場」タンパク質抽出固定化技術の開発
    静電気学会誌, http://www.iesj.org/content/files/pdf/papers/41/41-1-2.pdf
  10. 大重真彦, 馬場淑行, 高岩将太, 津田裕太, 福田泰基, 高橋俊介, 川上友則, 桂進司 (2016)
    静電技術を用いたグルコース燃料電池の電極作成
    静電気学会誌, http://www.iesj.org/content/files/pdf/papers/40/40-5-245.pdf
  11. Takahashi S, Motooka S, Usui T, Kawasaki S, Miyata H, Kurita H, Mizuno T, Matsuura S, Mizuno A, Oshige M, Katsura S. (2015)
    Direct single-molecule observations of local denaturation of a DNA double helix under a negative supercoil state.
    Analytical Chemistry, https://doi.org/10.1021/acs.analchem.5b00044
  12. Takahashi S, Usui T, Kawasaki S, Miyata H, Kurita H, Matsuura S, Mizuno A, Oshige M, Katsura S. (2014)
    Real-time single-molecule observations of T7 Exonuclease activity in a microflow channel.
    Analytical Biochemistry, https://doi.org/10.1016/j.ab.2014.04.012
  13. Takahashi S, Kawasaki S, Miyata H, Kurita H, Mizuno T, Matsuura S, Mizuno A, Oshige M, Katsura S. (2014)
    A new direct single-molecule observation method for DNA synthesis reaction using fluorescent replication protein A.
    Sensors (Basel), https://doi.org/10.3390/s140305174
  14. Miyata H, Yumoto K, Ito K, Sasahara M, Kawaura H, Oshima N, Takahashi S, Oshige M, Katsura S. (2013)
    Immobilization of His-tagged proteins through interaction with L-cysteine electrodeposited on modified gold surfaces.
    Key Engineering Materials, https://doi.org/10.4028/www.scientific.net/KEM.596.219
  15. Takahashi S, Kawasaki S, Yamaguchi K, Miyata H, Kurita H, Mizuno T, Matsuura S, Mizuno A, Oshige M, Katsura S. (2013)
    Direct Observation of Fluorescently Labeled Single-stranded λDNA Molecules in a Micro-Flow Channel.
    Journal of Fluorescence, https://doi.org/10.1007/s10895-013-1210-1
  16. Oshige M, Yumoto K, Miyata H, Takahashi S, Nakada M, Ito K, Tamegai M, Kawaura H, Katsura S. (2013)
    Immobilization of His-Tagged Proteins on Various Solid Surfaces Using NTA-Modified Chitosan.
    Open Journal of Polymer Chemistry, https://doi.org/10.4236/ojpchem.2013.31002

Review Papers

  1. 高橋俊介 (2022)
    DNAに焦点を当てた1分子蛍光イメージング解析法の開発
    細胞, https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202202251124070625
  2. 高橋俊介 (2022)
    DNA分子の物理的形態操作技術と1分子蛍光イメージングへの応用
    細胞, https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202202273373440160
  3. Takahashi S, Oshige M, Katsura S. (2021)
    DNA Manipulation and Single-Molecule Imaging
    Molecules, https://doi.org/10.3390/molecules26041050
  4. 大重真彦, 高橋俊介, 桂進司 (2018)
    電界印加による分子・生体分子操作―タンパク質分子の固定化技術―
    静電気学会誌, http://jglobal.jst.go.jp/public/201802249736533710

Book

  1. 柘植謙爾, 高橋俊介, 近藤昭彦 (2018)
    スマートセルインダストリー―微生物細胞を用いた物質生産の展望―
    第1編 ハイスループット合成・分析・評価技術
    第1章 ハイスループット長鎖DNA合成技術 OGAB法による長鎖DNA合成技術
    シーエムシー出版, https://www.cmcbooks.co.jp/products/detail.php?product_id=5447